Will you help me on my homework? OR Will you help me with my homework?

Examples:

1) Will you help me on my homework? (Incorrect)
2) Will you help me with my homework? (Correct)

If you want to use "on" in this kind of context.You need to expand the sentence as:
1) Will you help me on the matter of/question of/subject of...?

Cheers!
Naeem